|
KMID : 0380620200520010081
|
|
Korean Journal of Food Science and Technology
2020 Volume.52 No. 1 p.81 ~ p.88
|
|
|
Improvement of blood glucose control in type 2 diabetic db/db mice using Platycodon grandiflorum seed extract
|
|
Kim Tae-Yeong
Kim Seok-Joong
Imm Jee-Young
|
|
|
Abstract
|
|
|
|
The biological activities of Platycodon grandiflorum (PG) root extracts have been studied intensively, whereas there are limited number of studies on PG seed extract (PGSE). PGSE was prepared by ethanol extraction, and its antidiabetic effect was evaluated in mice with type 2 diabetes (C57BLKS/J-db/db). Results indicated that the administration of high-dose PGSE (600 mg/kg, wb) significantly stabilized the blood glucose levels, as evidenced by the results of the oral glucose tolerance test. Mice treated with high-dose PGSE exhibited significantly lower serum hemoglobin A1c, insulin, and leptin levels after eight weeks of feeding trial (p<0.05). High-dose PGSE administration significantly improved glucose uptake in the femoral muscle of db/db mice by activating both IRS-1/PI3K/AKT/AS160 and AMPK phosphorylation pathways. GLUT4 translocation from the cytosol to the plasma membrane increased 1.7-fold in the PGSE high-dose group. These results suggest that PGSE has potential for development as an antidiabetic agent.
|
|
|
KEYWORD
|
|
|
Platycodon grandiflorum, seed extract, db/db mice, anti-diabetic effect, cell signaling
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|